Psoriasis

is a chronic, complex, immunologically mediated, systematic disease that can

not only affect the skin but also the joints, and nails. It may coexist with

various other disorders such as depression, psoriatic arthritis, cardiovascular

diseases, diabetes mellitus, and metabolic syndrome. In particular, the

potential link between psoriasis and metabolic syndrome is worthy of an

attention issue. A dysregulated level of growth factors could potentially

contribute to the disturbances of keratinocyte proliferation, inflammation, and

severity of itch. However, the

pathophysiology of psoriasis and its comorbidities, such as metabolic syndrome,

remain incompletely elucidated. Growth factors and their abnormal metabolism may

be the potential link connecting this conditions. Overall, the objective of

this review is to analyze the role of growth factors disturbances in psoriasis

and in metabolic syndrome.

GF PRISMA_2020_checklist.docx References.docx Methodological approach.docx